Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure

Background and Research Motivation Alcohol abuse is a global health issue, affecting over 8% of the male population. Prolonged alcohol exposure can alter the homeostasis of neurons and synapses in the brain, leading to various mental disorders and cognitive deficits, especially in motor learning. Previous studies have shown that alcohol abuse cause...

Link Brain-wide Projectome to Neuronal Dynamics in the Mouse Brain

Background Introduction The brain is composed of different subtypes of neurons, which form complex neural networks through local and long-range synaptic connections. Understanding the functions of these neural networks requires knowledge of their connection patterns (projectome) and neuronal dynamics. Although advancements in mesoscale connectomics...

Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors

Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors

Thalamic Reuniens Nucleus Glutamatergic Neurons Mediated Colorectal Visceral Pain in Mice through 5-HT2B Receptors Background Irritable Bowel Syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is crucial for effectively alleviating abdominal pain in ...

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment Background and Research Significance Cervical cancer is a disease that seriously threatens the life and health of women. According to data from the International Agency for Research on Cancer (IARC), there were approximately...

Federated Learning Using Model Projection for Multi-Center Disease Diagnosis with Non-IID Data

Federated Learning Using Model Projection for Multi-Center Disease Diagnosis with Non-IID Data

Federated Learning Using Model Projection for Multi-Center Disease Diagnosis Background Introduction With the rapid development of medical imaging technology, research on automated diagnostic methods has shown good performance on single-center datasets. However, these methods often find it difficult to generalize to data from other healthcare facil...

Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity

Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity

Single-Cell Analysis of Anti-BCMA CAR-T Cell Therapy in Patients with Central Nervous System Autoimmune Diseases Introduction Chimeric Antigen Receptor (CAR) T-cell therapy has shown potential long-term control in treating central nervous system (CNS) autoimmune diseases. This paper investigates the effects of anti-BCMA (B-cell maturation antigen) ...

Serine Enrichment in Tumors Promotes Regulatory T Cell Accumulation Through Sphinganine-Mediated Regulation of c-Fos

Scientific Paper Report Discoveries in the field of science often have significant implications for understanding natural phenomena and improving practical applications. Recently, a research paper published in Science Immunology titled “Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-...

TH17-Intrinsic IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation

TH17-Intrinsic IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation

TH17 Endogenous IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation Academic Background Steroid resistance is a major challenge in managing various inflammatory diseases, including autoimmune neuroinflammation. T helper 17 (TH17) cells are widely believed to be associated with steroid resistance. However, the specific mechani...

Nucleobase Adducts Bind MR1 and Stimulate MR1-Restricted T Cells

Nucleotide Adduct Binding MR1 and Activation of MR1-Restricted T Cells Academic Background MR1T cells, a recently discovered class of T cells, can recognize antigens presented by MHC class I-related molecule MR1 without microbial infection. These cells exhibit both helper and cytotoxic properties in vitro, but the endogenous antigens they recognize...

Heart Failure Promotes Multimorbidity Through Innate Immune Memory

Heart Failure Promotes Multimorbidity Through Innate Immune Memory

Heart Failure Promotes Multimorbidity through Innate Immune Memory Research Background Despite significant medical advances, the mortality rate of heart failure (HF) remains high, necessitating new therapeutic targets. HF patients often experience acute decompensation and develop comorbidities such as chronic kidney disease and frailty syndrome. Th...