Human Cortical Neurogenesis is Altered via Glucocorticoid-Mediated Regulation of ZBTB16 Expression

Human Cortical Neurogenesis is Altered via Glucocorticoid-Mediated Regulation of ZBTB16 Expression

Glucocorticoids Alter Human Cortical Neurogenesis by Regulating ZBTB16 Expression Background Introduction During pregnancy, glucocorticoids (GCs) are crucial steroid hormones for the development of the central nervous system (CNS). GCs regulate the development of fetal organs, particularly the lungs and brain. However, when GC levels exceed the phy...

Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function

Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function

Astrocytes Secrete Neurocan to Control Inhibitory Synapse Formation and Function In recent years, the role of neuron-glial cell interactions in synapse formation and maintenance of synaptic function has become a hot topic in neuroscience research. This paper, published by Dolores Irala et al. from Duke University Medical Center in the May 2024 issu...

p-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...

The Crosstalk Between Macrophages and Cancer Cells Potentiates Pancreatic Cancer Cachexia

Interactive Mechanisms Between Cancer Cells and Macrophages Facilitate Pancreatic Cancer Cachexia Background Pancreatic cancer is currently the third leading cause of cancer-related death in the United States and is expected to become the second leading cause of cancer death within the next decade. Unfortunately, more than 80% of pancreatic cancer ...

Tumor Cell-Intrinsic Epigenetic Dysregulation Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer

Tumor Cell-Intrinsic Epigenetic Dysregulation Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer

Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts Heterogeneity to Metabolically Support Pancreatic Cancer Authors Ningning Niu, Qingshen Xu, Wang Zheng, …, Kurong Jiang, Fengshi Yu, Xue Xu Jing published an article titled “Intrinsic Epigenetic Dysregulation in Tumor Cells Shapes Cancer-Associated Fibroblasts He...

Putting the STING Back into BH3-Mimetic Drugs for TP53-Mutant Blood Cancers

Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...

Molecular Targets of Glucocorticoids that Elucidate Their Therapeutic Efficacy in Aggressive Lymphomas

Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells in Patients with Checkpoint-Induced Colitis

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells in Patients with Checkpoint-Induced Colitis

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells Academic Background Checkpoint inhibitors (CPIs) have revolutionized cancer treatment by blocking immune regulatory signals mediated by checkpoint molecules, restoring T cell-mediated tumor clearance. However, these therapies also lead to a range of immune-related adverse events (IRAEs), wi...

Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization

Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization

Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...