This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...
Analysis of Gender Differences in Transcriptomes of Postmortem Brain Tissues from Psychiatric Patients Background Gender differences in psychiatric patients are a well-documented phenomenon. Disorders such as Schizophrenia (SCZ), Bipolar Disorder (BD), and Autism Spectrum Disorder (ASD) all exhibit significant gender differences. However, the speci...
Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...
Integrated Analysis of Blood DNA Methylation, Genetic Variation, Circulating Proteins, microRNAs, and Kidney Failure in Type 1 Diabetes Research Background Diabetic Kidney Disease (DKD) is one of the major complications of Type 1 Diabetes (T1D). Approximately 40% of T1D patients develop DKD, and 10% to 15% eventually progress to Kidney Failure (KF)...
Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...
High-Fidelity Fatigue-Resistant Muscle Control Through Closed-Loop Optogenetic Neural Modulation Background Introduction Skeletal muscle is the biological actuator for almost all movements in animals and humans. However, under various neurological conditions, the communication pathways between the central nervous system and neuromuscular components...
Liver Danger Signal Triggers TREM2+ Macrophage-Mediated MS4A7-Dependent Inflammasome Activation Driving Steatohepatitis Background and Research Motivation In recent years, with the increasing incidence of metabolic dysfunction-associated steatohepatitis (MASH), its pathological mechanisms have garnered significant attention. MASH, formerly known as...
Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality Summary This scientific report titled “Simultaneously Recording Up to a Million Neurons’ Cortical Dynamics Reveals Unbounded Scaling of Neuronal Quantity and Dimensionality,” published in the journal Neuron (Volume 1...
Application of Functional Ultrasound Imaging in the Study of the Human Spinal Cord Background Introduction The spinal cord is an important center for sensory and motor integration in the nervous system, responsible for monitoring the kinematics and posture of various body parts. Interruption of spinal cord information flow due to injury or disease ...
Background Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, regulating neuronal activity and plasticity through two distinct modes: phasic and tonic. However, our understanding of the mechanisms and physiological functions of GABA transmission in glial cells remains limited. Glial cells, especially astrocytes, ca...