Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

Comparison of Tumor Burden Quantification between Liquid Biopsy and CT Academic Background In the era of precision medicine, the validation of non-invasive biomarkers faces numerous challenges. Tumor burden, as a potential prognostic marker, has been demonstrated to hold significant value in various studies. Tumor burden refers to the total amount ...

Impact of an Epstein-Barr Virus Serology-Based Screening Program on Nasopharyngeal Carcinoma Mortality: A Cluster-Randomized Controlled Trial Academic Background Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Asia, particularly in southern China. Approximately 85% of NPC cases occur in Asia, with the incidence being...

Report on the Study of Cardiac Dysfunction Among Breast Cancer Survivors Academic Background Breast cancer is the most common cancer diagnosed in women. Advances in early detection and novel therapeutics have yielded 5-year survival rates exceeding 90%. However, with over four million breast cancer survivors in the United States today, the quality ...

Effectiveness of a Cardiovascular Health Electronic Health Record Application for Cancer Survivors in Community Oncology Practice Academic Background The cardiovascular health (CVH) of cancer survivors has become an increasingly important concern. Studies have shown that cancer survivors generally have poorer cardiovascular health, partly due to th...

The Impact of a Statewide Regionalization Policy on Travel Distance for Initial Breast Cancer Surgery Academic Background Breast cancer is one of the most common cancers among women globally, and the quality of treatment and patient survival rates are closely related to the allocation of medical resources. Studies have shown that high-volume medica...

Academic Background Acute Myeloid Leukemia (AML) is a malignant blood disorder, with the core of its treatment being induction chemotherapy, typically involving a combination of cytarabine and anthracyclines (such as daunorubicin). Although this treatment regimen has been in use since the 1980s, questions regarding the optimal dose of daunorubicin ...

Academic Background Acute leukemia is a malignant hematologic disease caused by genetic mutations in hematopoietic cells, characterized by a block in differentiation during hematopoiesis and uncontrolled cellular proliferation. Among these, KMT2A gene rearrangements (KMT2A-rearranged, KMT2Ar) occur in up to 10% of acute leukemias in children and ad...