Study on Melanoma Suppression by Non-Thermal Atmospheric Pressure Plasma via the PI3K-AKT-ZEB1 Axis Academic Background Melanoma is the most aggressive and deadly form of skin cancer, particularly in its advanced stages, making treatment extremely challenging. Although recent advancements in targeted therapy and immunotherapy have improved patient ...

Prognostic Value of the CONUT Score in Immune Checkpoint Inhibitor Therapy for Metastatic Malignant Melanoma Academic Background The incidence of malignant melanoma (MM) is increasing annually, with approximately 20% of patients progressing to advanced or metastatic melanoma. Immune checkpoint inhibitors (ICIs) have significantly transformed the tr...

Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

CDK2 Activity Interference on ERK and p38 KTR Signals and Computational Correction Methods Recently, a paper published in Cell Systems by authors Timothy E. Hoffman, Chengzhe Tian, Varuna Nangia, and others revealed the interference of cyclin-dependent kinase 2 (CDK2) on the kinase translocation reporter (KTR) signals in the extracellular signal-re...

Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems Academic Background Glioblastoma (GBM) is the most common and aggressive type of brain cancer, with an extremely poor prognosis and a five-year survival rate of less than 10%. Despite decades of extensive research in drug therapy, radiation therapy, ...

Targeted Drug Delivery Using Self-Unrolling Sheets in Magnetically Actuated Capsules Background Gastrointestinal (GI) diseases, such as inflammatory bowel disease, GI bleeding, and cancer, are significant global health issues. Traditional treatment methods, such as endoscopy and oral medications, though effective to some extent, have many limitatio...

Predicting and Monitoring the Toxicity of Immune Checkpoint Inhibitors: Breakthrough Application of the DysPred Deep Learning Framework Academic Background Immune checkpoint inhibitors (ICIs) represent a major breakthrough in cancer immunotherapy in recent years, enhancing the body’s antitumor immune response by inhibiting immune checkpoint signali...

Choline Phosphate-Based Antigen Capture Strategy Boosts In Situ Tumor Vaccine Research: A Novel Immunotherapy Approach In the field of cancer immunotherapy, in situ tumor vaccines have garnered significant attention for their ability to harness a patient’s immune system to target tumors. However, challenges remain in their clinical application. To ...