Qualitative Study Report on the Experience of Extensive Germline Sequencing in Children with Cancer Aged 12-18 Background Introduction With the development of genetic sequencing technology, germline DNA sequencing has gradually become a routine practice in pediatric cancer care. Recent studies estimate that about 10% of children with cancer have ge...
Detection of a 39 kb structural variant causing Lynch syndrome using optical genome mapping and nanopore sequencing Research Background Lynch syndrome (LS) is a hereditary cancer syndrome primarily caused by pathogenic germline variants in four genes of the MMR (mismatch repair) gene family: MLH1, MSH2, MSH6, and PMS2. This syndrome is characterize...
Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...
Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment in Human Hepatocellular Carcinoma via the CCL20/CCR6 Axis Background Macrophages are a major component of the tumor microenvironment (TME) and regulate the entire tumor process. In the TME, macrophages exhibit dynamic heterogeneity and plasticity, which affects their role ...
Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...
Paper Report Research Background Myeloid-Derived Suppressor Cells (MDSCs) are a major driving force in tumor immune suppression. Understanding their mechanisms can provide new therapeutic targets to improve anti-tumor immunity, as the development and immunosuppressive function of these cells directly affect anti-tumor immune responses. In preclinic...
Unique Foxp3 Palmitoylation Regulates Tregs Function through Palmitoyltransferases Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing excessive immune responses. As important suppressors of immune reactions, Tregs help maintain immune tolerance, thereby preventing autoimmune diseases. However, in the tum...
Prediction of Invasiveness and Treatment Resistance Behavior of Pituitary Neuroendocrine Tumors Based on Genome-Wide Loss of Heterozygosity Background: Pituitary neuroendocrine tumors (PitNETs) are mostly benign, but a small portion exhibit invasive and treatment-resistant behaviors, continuing to grow or metastasize even after surgery, conventiona...
Association of Adverse Transcriptomic Subtypes of Non-WNT/Non-SHH Medulloblastoma with the Dominance of Proliferative and Progenitor-like Subpopulations Research Background Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Based on molecular characteristics, the medical community typically cl...
Study of Tau Protein Accumulation in Brain Vasculature in Alzheimer’s Disease Background Introduction Alzheimer’s disease is characterized by neurodegeneration, with primary pathological features including amyloid plaques and neurofibrillary tangles (NFTs). These tangles are composed of tau protein, and these pathological changes are closely relate...