Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in MAPK Inhibitor–Resistant NRAS-Mutant Melanoma

Academic Background NRAS-mutant (NRASmut) melanoma is a highly aggressive tumor type, accounting for nearly 30% of all melanoma cases. NRAS is an oncogene that persistently activates the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a critical role in melanoma development. However, despite extensive research on MAPK pathway...

Age-Dependent Macropinocytosis Drives Resistance to KRAS-G12D–Targeted Therapy in Advanced Pancreatic Cancer

Academic Background and Problem Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with an extremely low five-year survival rate, primarily due to late diagnosis and limited treatment options. Approximately 95% of PDAC patients harbor KRAS mutations, with the KRAS-G12D mutation being the most common. Although KRAS mutations have long b...

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Multi-Ancestry Genome-Wide Association Study Reveals New Loci for Prostate-Specific Antigen Levels and Improves Prediction Across Ancestral Groups Research Background and Problem Statement Prostate-specific antigen (PSA) is a protein secreted by the prostate gland, commonly used for prostate cancer screening. However, PSA levels are influenced not ...

FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy

Research Background and Problem Introduction Protein O-GlcNAc glycosylation is an important post-translational modification that plays a critical role in cellular metabolic plasticity. Aberrant O-GlcNAc glycosylation levels have been observed in various cancers, including endometrial cancer (EC), a common malignancy in women. However, clinical char...

Cancer Cells Avoid Ferroptosis Induced by Immune Cells via Fatty Acid Binding Proteins

Cancer Cells Evade Immune Cell-Induced Ferroptosis via Fatty Acid Binding Protein 7 Background Introduction Cancer creates an immunosuppressive environment that hinders immune responses, allowing tumors to grow and resist treatment. The immune system combats this by inducing ferroptosis in tumor cells through CD8+ T cells. Ferroptosis is a type of ...

5-HT Orchestrates Histone Serotonylation and Citrullination to Drive Neutrophil Extracellular Traps and Liver Metastasis

5-HT Orchestrates Histone Serotonylation and Citrullination to Drive Neutrophil Extracellular Traps and Liver Metastasis

Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...

Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study

Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study Academic Background Introduction Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor, accounting for nearly 50% of all primary brain tumors in adults. It primarily originates from astro...

Hybridization-Based Discovery of Novel Quinazoline-2-Indolinone Derivatives as Potent and Selective PI3Kα Inhibitors

Research and Development of a Novel PI3Kα Inhibitor: Molecular Hybridization Technology Leads to a Breakthrough in Lung Cancer Treatment Academic Background Cancer, particularly non-small cell lung cancer (NSCLC), is the second leading cause of death worldwide. Currently, chemotherapy is the primary treatment method, but due to its lack of targetin...

HNRNPR-mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis

HNRNPR-Mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis In recent years, hepatocellular carcinoma (HCC) has become one of the leading causes of cancer-related deaths worldwide due to its highly invasive and metastatic nature. The mechanisms underlying HCC metastasis are complex, with abnormal alternative splicing (AS) playing...

NCAPD3 Promotes Diffuse Large B-Cell Lymphoma Progression Through Modulating SIRT1 Expression in an H3K9 Monomethylation-Dependent Manner

Study on the Pro-Cancer Mechanism and Application Value of NCAPD3 in Diffuse Large B-Cell Lymphoma Academic Background Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy, characterized by significant clinical and biological heterogeneity. Although advances in treatment have been made in recent years, a subset of patie...