RNF2 Promotes Chondrosarcoma Progression by Regulating Ubiquitination of CBX7 Academic Background Chondrosarcoma (CHS) is a malignant tumor composed of hyaline cartilage matrix and chondrocytes, ranking as the second most common primary bone tumor after osteosarcoma, accounting for 20%-27% of all primary malignant bone tumors. Although the 5-year s...

RhoF Promotes Snail1 Lactylation by Enhancing PKM2-Mediated Glycolysis to Induce Pancreatic Cancer Cell Endothelial–Mesenchymal Transition Academic Background Pancreatic cancer (PC) is a highly malignant tumor characterized by late diagnosis, strong invasiveness, and resistance to systemic therapy, leading to poor patient prognosis. Despite recent ...

Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy Academic Background Cancer is one of the leading causes of global mortality, significantly impacting patients’ quality of life. In recent years, photodynamic therapy (PDT) has garnered considerable attention as a promising technology for cancer...

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

The Potential Role of Platelet-Activating Factor in Cancer Immunotherapy Background Cancer immunotherapy has been a significant breakthrough in cancer treatment in recent years, but its efficacy is still limited by the immunosuppressive mechanisms within the tumor microenvironment (TME). The TME supports the differentiation and proliferation of mye...

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...

APOBEC3C-Mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression Academic Background Clear cell renal cell carcinoma (CCRCC) is the most common subtype of kidney cancer, accounting for approximately 75% of all kidney cancer cases. Although immunotherapy has shown some potential in treating CCRCC, the treatment of metastatic C...