Multisite DNA Methylation Alterations of Peripheral Blood Mononuclear Cells Serve as Novel Biomarkers for the Diagnosis of AIS/Stage I Lung Adenocarcinoma: A Multicenter Cohort Study

Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...

Utilizing Bifurcated Allogeneic Vein Grafts: A Novel Approach for Preventing Sinistral Portal Hypertension Following Pancreaticoduodenectomy. A 10-Year Before and After Study

Utilizing Bifurcated Allogeneic Vein Grafts to Prevent Sinistral Portal Hypertension Following Pancreaticoduodenectomy Academic Background Pancreatic cancer is a highly malignant tumor with a poor prognosis, with a 5-year survival rate of less than 10%. The early invasive growth of pancreatic cancer often involves the portal vein system, particular...

Pattern and Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma – A Case–Control Study Based on Liver Panoramic Digital Pathology

Study on the Pattern and Extent of Intrahepatic Infiltration in Perihilar Cholangiocarcinoma Academic Background Perihilar cholangiocarcinoma (PHCC) is one of the most common malignancies of the biliary system, and its treatment primarily relies on radical surgical resection. However, despite advancements in surgical techniques, the postoperative r...

Comparison of Long-Term Survival of Neoadjuvant Therapy Plus Surgery Versus Upfront Surgery and the Role of Adjuvant Therapy for T1b-2N0-1 Esophageal Cancer: A Population Study of the SEER Database and Chinese Cohort

Comparative Study on Treatment Strategies for Esophageal Cancer Academic Background Esophageal cancer is one of the digestive system tumors with high incidence and mortality rates worldwide, particularly in Asia, where the incidence of esophageal squamous cell carcinoma (SCC) is notably prominent. Although significant progress has been made in the ...

Hepatic Arterial Chemotherapy Infusion Combined with Tyrosine Kinase Inhibitors and PD-1 Inhibitors for Advanced Hepatocellular Carcinoma with High Risk: A Propensity Score Matching Study

Study on the Application of Hepatic Arterial Chemotherapy Combined with Targeted and Immunotherapy in Advanced Liver Cancer Background Liver cancer is the sixth most commonly diagnosed cancer globally and the third leading cause of cancer-related deaths. Most patients are diagnosed at an advanced stage, losing the opportunity for surgical resection...

Assessing the Global Burden of Mesothelioma: Trends, Socioeconomic Influences, and Asbestos Exposure – A Retrospective Cohort Study

Global Burden Assessment of Mesothelioma – Trends, Socioeconomic Influences, and Asbestos Exposure Academic Background Mesothelioma is a rare form of cancer that primarily affects the lining of the lungs (pleura) but can also occur in the lining of the abdominal cavity (peritoneum), heart, or testicles. Due to its rarity and long latency period, me...

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer: Insights from Quantitative Analysis and Retrospective Cohort Studies

Evaluating the Effectiveness of Cytoreductive Surgery in Oligometastatic Prostate Cancer Academic Background Prostate cancer is the second most common malignancy among men globally, particularly in its advanced stages, where it is often accompanied by metastases, significantly impacting patients’ quality of life and prognosis. Oligometastatic prost...

Hepatic Arterial Infusion Chemotherapy-Based Conversion Hepatectomy in Responders Versus Nonresponders with Hepatocellular Carcinoma: A Multicenter Cohort Study

Hepatic Arterial Infusion Chemotherapy (HAIC)-Based Conversion Hepatectomy in Patients with Hepatocellular Carcinoma Academic Background Hepatocellular carcinoma (HCC) is one of the most common liver malignancies worldwide, particularly in China, where its incidence and mortality rates remain high. Despite advancements in treatment strategies, radi...

Observational Cohort Study on Safety and Efficacy of Robotic Thyroidectomy with Super-Meticulous Capsular Dissection versus Open Surgery for Thyroid Cancer: Postoperative Dynamic Risk Assessment of Radioactive Iodine Therapy

Comparative Study of Robotic-Assisted Thyroidectomy versus Traditional Open Surgery in Thyroid Cancer Treatment Academic Background The incidence of thyroid cancer has been increasing annually, with differentiated thyroid carcinoma (DTC) accounting for over 90% of all thyroid cancer cases. Currently, the standard treatment for DTC includes surgical...

Reoperation for Ipsilateral Local Recurrence Following Prior Nephron-Sparing Surgery: Innovative Surgical Insights from a High-Volume Urological Center with Cross-Sectional Study

Innovative Surgical Strategies for Reoperation of Local Recurrence in Renal Cell Carcinoma Academic Background Renal cell carcinoma (RCC) is one of the most common malignant tumors in adults, accounting for 5% of malignancies in males and 3% in females. Although surgery remains the standard treatment for localized RCC, nephron-sparing surgery (NSS)...