Contribution of HMHA1/ARHGAP45 Expression Induced by Hypoxia and Post-Radiation Reoxygenation to Cancer Cell Invasion: An HIF-Dependent Mechanism Background and Motivation Prior studies have extensively demonstrated that cancer cells in solid tumors acquire malignant characteristics such as invasiveness and treatment resistance under hypoxic condit...
Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...
Study on the Key Role of Oncofetal snrpe in the Tumorigenesis and Progression of Hepatocellular Carcinoma Research Background and Purpose Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. However, due to the lack of understanding of key molecular events in tumors, effec...
Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...
Effects of Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Ovarian Cancer Patients: PADOVA Trial Results Academic Background Ovarian cancer is the seventh most common cancer among women, usually detected at an advanced stage, with an overall 5-year survival rate as low as 30-40%. Standard ovarian...
In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...
Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...
The Path to Individualized Adjuvant Chemotherapy for All Four Types of Non-Pancreatic Periampullary Cancers: An International Multi-Method Cohort Study Background and Study Aim Although duodenal adenocarcinoma (DAC), intestinal type ampullary adenocarcinoma (AMPIT), pancreatobiliary type ampullary adenocarcinoma (AMPPB), and distal cholangiocarcino...
Epidemiological Study on Menopausal Hormone Therapy and Breast Cancer Risk Introduction This study aims to explore the relationship between Menopausal Hormone Therapy (HT) and the risk of Breast Cancer (BC). While HT can relieve menopausal symptoms in women (such as hot flashes, fatigue, and urinary pain), it may also pose other health risks like a...
Epigenetic Activation of Sox11 in Recurrence and Progression of Ductal Carcinoma In Situ Background Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer characterized by the excessive proliferation of luminal epithelial cells surrounded by myoepithelial cells. DCIS accounts for approximately 25% of breast cancer screenings, and its poten...