High Cellular Plasticity State of Pediatric Medulloblastoma: A Comprehensive Analysis of Local Recurrence and Distant Dissemination Research Background Medulloblastoma (MB) is a highly heterogeneous pediatric intracranial malignancy. While current treatments (surgery, radiotherapy, and chemotherapy) improve survival rates after initial treatment, r...

Exploring the Impact of Endocrine-Targeting Therapies on Breast Microbiota and Their Potential in Breast Cancer Prevention and Treatment Breast cancer is one of the most commonly diagnosed types of cancer in women. Despite significant advancements in diagnosis and treatment, the mortality rate remains high, with over 40,000 deaths annually in the U...

Dual Ferroptosis Induction via FTH1 Targeting: A New Therapeutic Strategy for Triple-Negative Breast Cancer (TNBC) Background: Why Conduct This Study? Breast cancer is one of the most common cancer types worldwide, accounting for 11.7% of all new cancer cases globally. Among its several subtypes, triple-negative breast cancer (TNBC) stands out for ...

Exploring the Applications of Single-Molecule Systems for Detection and Monitoring of Plasma-Circulating Nucleosomes and Oncoproteins in Diffuse Midline Glioma Research Background and Problem Overview Diffuse Midline Glioma (DMG) is a highly aggressive brain tumor primarily affecting children with extremely high mortality rates. This type of tumor ...

The Potential of Oncolytic Cytomegaloviruses Expressing EGFR-Retargeted Fusogenic Glycoprotein Complex and Drug-Controlled IL-12 in Cancer Immunotherapy Background and Objectives In recent years, cancer viroimmunotherapy has emerged as a promising research focus in the field of cancer treatment. This therapy leverages viruses to infect tumor cells,...

Using Liposomal Doxorubicin Neoadjuvant Chemotherapy to Enhance Immune Protection of Tumor Membrane Antigen-Based Nanovaccine Background and Significance Surgical resection remains the primary treatment for solid tumors, but postoperative tumor recurrence and metastasis continue to be major challenges. A promising emerging strategy in personalized ...

Tumor Metabolic Reprogramming Identifies Key Vulnerability in Pediatric Malignant Tumors – Comprehensive Research Based on Organoid Models Background Malignant Rhabdoid Tumors (MRT) are highly invasive pediatric cancers that primarily affect infants and can develop throughout the body, with the intracranial variant known as Atypical Teratoid/Rhabdo...

Research Report on Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely low survival rate, with a 5-year survival rate of less than 15%. The primary reasons are early tumor metastasis and high resistance to chemotherapy and ra...

Background Introduction This study focuses on malignant pleural mesothelioma (MPM), a rare and highly lethal cancer strongly associated with asbestos exposure. Most patients are diagnosed at advanced stages, with a survival time of only 12 to 15 months, and traditional treatments revolve around platinum-based chemotherapy. However, treatment paradi...

Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...