Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed

Research Report on Whether the Public Should Be Allowed to Use Drug Enhancers Introduction In recent years, some individuals have started using drugs to enhance cognitive and socio-emotional functions and have requested off-label prescriptions from doctors for neuroenhancement (e.g., stimulants). However, discussions about whether such uses should ...

Efficacy of Ofatumumab and Teriflunomide in Patients with Relapsing MS from Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses

Academic Paper Report Academic Background Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system characterized by the destruction of myelin and axons, leading to neurological dysfunction and progressive disability. It is estimated that there are approximately 2.8 million MS patients worldwide, with over 700,000 affected in...

Association Between Body Composition Patterns, Cardiovascular Disease, and Risk of Neurodegenerative Disease in the UK Biobank

Study on the Association# Study on the Association Between Body Composition Patterns, Cardiovascular Diseases Between, Body and Neurodegenerative Composition Disease Risks Background Neurodegenerative Patterns diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease, (PD), currently affect over Cardiovascular Diseases, and Neuro60degene...

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age from Blind Ultrasound Sweeps

Diagnostic Accuracy of AI Tools for Estimating Gestational Age Based on Blind Ultrasound Scanning Background Accurate estimation of gestational age (GA) is the foundation of good prenatal care, typically achieved through ultrasound examinations. However, many low-resource areas lack sufficient ultrasound equipment, making accurate GA estimation cha...

Electroencephalography-Guided Anesthesia and Delirium in Older Adults after Cardiac Surgery

EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...

Efficacy and Safety of Pamrevlumab in Idiopathic Pulmonary Fibrosis: The Zephyrus-1 Randomized Clinical Trial

Pamrevlumab Treatment for Idiopathic Pulmonary Fibrosis: The ZEPHYRUS-1 Randomized Clinical Trial Idiopathic Pulmonary Fibrosis (IPF) is a rare interstitial lung disease that typically occurs in adults over 60 years old. It is characterized by cough, breathlessness, and fatigue. This disease leads to progressive loss of lung function, decreased exe...

A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users: A Randomized Clinical Trial

E-cigarette Cessation SMS Program: A Randomized Clinical Trial Study Targeting Adolescent E-cigarette Users Background In recent years, e-cigarettes have become the most widely used tobacco product among American adolescents. Statistics from 2023 show that over 2.1 million adolescents reported current use of e-cigarettes, including 10% of high scho...

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores with Patient Outcomes

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores with Patient Outcomes

Association Between Milestone Ratings and Certification Exam Scores of Medical Residents and Patient Outcomes Background In the United States, the education and competency assessment of internal medicine residents are primarily conducted through two methods: the Milestone assessment system and the American Board of Internal Medicine (ABIM) certific...