APP/PS1 Mouse Study Reveals Link Between Chronic Induced Epilepsy and Alzheimer’s Disease Background Alzheimer’s Disease (AD) is the most common type of dementia globally, affecting over 55 million people. The typical pathological feature of AD is the deposition of amyloid-β (Aβ) in the brain. Although Aβ deposition and the mechanisms it triggers p...

The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...

Epilepsy is one of the most common neurological disorders, with temporal lobe epilepsy (TLE) being the most prevalent form of drug-resistant epilepsy in adults. Numerous studies have indicated that TLE involves not only pathological changes in the medial temporal lobe but also affects widespread brain structures and functions. In this scientific re...

New Discoveries in Brain Science: The Relationship Between Early Lateralization of Dorsal White Matter Tracts Targeting Broca’s Area and Language Development Research Background Language development is one of the key areas in human cognitive science. Existing research indicates that language functions in the adult brain exhibit significant laterali...

Analysis of the Effect of Central LEAP-2 on Food Intake and Its Impact on Nucleus Accumbens Dopamine Release Background Introduction Gut-brain peptides such as ghrelin and their receptors have been established as important factors in regulating hunger and reward processing. However, the liver-expressed antimicrobial peptide 2 (Leap2), an inverse ag...

This academic paper, authored by researchers Elizabeth C. Heaton, Esther H. Seo, Laura M. Butkovich, Sophie T. Yount, and Shannon L. Gourley, primarily explores the role of the melanocortin system in the dorsal striatum in controlling goal-directed behavior and inflexible behavior, particularly in inhibiting habitual behavior in the dorsolateral st...

A Panoramic View of Whole Genome Repetitive Sequences in Cancer and Circulating Free DNA Research Background and Significance Throughout the development of cancer and other diseases, genetic changes in repetitive sequences within the genome are a significant characteristic. However, standard sequencing methods struggle to effectively characterize t...

A Visualization Microdisplay for Neuronal Activity on the Brain Surface Using Electroencephalography Background Introduction Current functional mapping in neurosurgery primarily relies on verbal communication between neurosurgeons and electrophysiologists. These processes are time-consuming and have limited resolution. Additionally, the electrode g...

Major Breakthrough in Brain Science: Multimodal MRI Reveals Brainstem Connectivity Maintaining Human Consciousness and Wakefulness Background Introduction Consciousness comprises two fundamental components: wakefulness and awareness. Despite significant progress in understanding the cortical networks related to consciousness over the past two decad...

Utilizing Electronic Health Record Features to Identify Undiagnosed Patients with Common Subtype of Immunodeficiency Recently, Johnson and colleagues published a study titled “Electronic health record signatures identify undiagnosed patients with common variable immunodeficiency disease” in Science Translational Medicine. This research utilizes ele...