NUDT21 Regulates Macrophage Hyperactivation via the Autophagy Pathway Academic Background The inflammatory response is a critical component of the body’s immune defense, facilitating pathogen clearance and tissue repair. However, dysregulation of the inflammatory response can lead to chronic inflammatory diseases such as inflammatory bowel disease ...

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer Academic Background Breast cancer is one of the most common cancers in women, and endocrine therapy (e.g., tamoxifen) is the standard treatment for estrogen receptor α (ER)-positive ...

Summary of the Academic Paper Report on “Century-Old Herbarium Specimen Provides Insights Into Pierce’s Disease of Grapevines Emergence in the Americas” Introduction Pierce’s Disease (PD) of grapevines, caused by the bacterial subspecies Xylella fastidiosa subsp. fastidiosa (Xff), poses a severe threat to the viticulture industry. However, its geog...

This study explores the necessity of quickly recognizing and avoiding predators in the natural environment, which is crucial for juvenile animals due to their increased vulnerability to predators. However, it remains unclear whether neonatal vertebrates can rapidly acquire such skills and the underlying neural mechanisms. Zebrafish, a widely used m...

“PITX2 Expression and Neanderthal Introgression in HS3ST3A1 Contribute to Variation in Tooth Dimensions in Modern Humans” Source of the Research This paper was authored by Qing Li, Pierre Faux, Emma Wentworth Winchester, and others, and published on January 6, 2025, in the journal Current Biology. The authors come from various research institutions...

Academic Report on the Study of Layer-Specific Anatomical and Physiological Characteristics of the Retinal Neurovascular Unit Background and Problem Statement Retinal processing, similar to all neural computations, is metabolically expensive and involves the dynamic regulation of blood flow, known as neurovascular coupling (NVC). The retina is supp...

Report on the Study of the Impact of ANCV1R Gene Deficiency on Pheromone Detection and Sexual Behavior in Mice Background Introduction In mammals, pheromones are crucial chemical signals that regulate social and sexual behaviors. Pheromone detection is mediated by the vomeronasal organ (VNO), which uses vomeronasal sensory neurons (VSNs) to recogni...

Diffusion-Based Feature Augmentation: A Novel Approach for Multiple Instance Learning in Whole Slide Images Academic Background and Research Motivation In computational pathology, effectively analyzing Whole Slide Images (WSIs) is a burgeoning area of research. WSIs are ultra-high-resolution images with a broad field of view and are widely employed...

Innovative Advances in Wearable Single-Transducer Echomyography Systems: From Muscle Dynamics Monitoring to Complex Gesture Tracking Academic Background and Research Significance In recent years, wearable electronic devices have garnered significant attention for their enormous potential in health monitoring and human-machine interaction. Electromy...

Digitally Embroidered Metamaterial Biosensor: Non-Contact Physiological Monitoring in Dynamic Environments Recent years have witnessed rapid development of sensor technologies driven by demands in smart vehicles, aviation safety, and health monitoring. However, for physiological signal detection in dynamic environments, traditional sensors face sig...