AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...

Malignant Glioma (MG) Report Malignant Glioma (MG) is the most common type of primary malignant brain tumor. Surgical resection of MG remains the cornerstone of treatment, and the extent of resection is highly correlated with patient survival. However, it is difficult to distinguish tumor tissue from normal tissue during surgery, which greatly limi...

Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...

Multi-Level Feature Exploration and Fusion Network for Prediction of IDH Status in MRI Background Glioma is the most common malignant primary brain tumor in adults. According to the 2021 World Health Organization (WHO) classification of tumors, genotype plays a significant role in the classification of tumor subtypes, especially the isocitrate dehy...

In modern medical diagnostics and clinical research, Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) technology provides significant information regarding tissue pathophysiology. By fitting a Tracer-Kinetic (TK) model, pharmacokinetic (PK) parameters can be extracted from time-series MRI signals. However, these estimated PK parameter...

Classification of 3D MRI Gliomas and Alzheimer’s Disease Based on the Siamese-Transport Domain Adaptation Framework Background In computer-aided diagnosis, 3D magnetic resonance imaging (MRI) screening plays a vital role in the early diagnosis of various brain diseases, effectively preventing the deterioration of the condition. Glioma is a common m...

DeepSleepNet: An Automatic Sleep Stage Scoring Model Based on Single-Channel EEG Background Introduction Sleep has a significant impact on human health, and monitoring sleep quality is crucial in medical research and practice. Typically, sleep experts score sleep stages by analyzing various physiological signals such as electroencephalogram (EEG), ...

In recent years, Virtual Reality (VR) technology has become increasingly common, with related hardware becoming more affordable. For example, current head-mounted displays (HMDs) on the market not only offer high-resolution displays but also feature precise head and handheld controller tracking. Initially, these technologies were mostly used in the...

In recent years, due to the high incidence and lethality of brain tumors, rapid and accurate detection and classification of brain tumors have become particularly important. Brain tumors include both malignant and non-malignant types, and their abnormal growth can cause long-term damage to the brain. Magnetic Resonance Imaging (MRI) is a commonly u...

Sleep stage classification is crucial for sleep quality assessment and disease diagnosis. However, existing classification methods still face numerous challenges in handling the spatial and temporal features of time-varying multi-channel brain signals, coping with individual differences in biological signals, and model interpretability. Traditional...