Study on Laser-Induced Olfactory Bulbectomy in Zebrafish as a Novel Model for Affective Syndrome Background Affective disorders, such as depression, are common mental health issues worldwide. Although rodent models have played a significant role in depression research, their cross-species applicability has limitations. Zebrafish (Danio rerio), as a...

The Interaction Between A2A Receptor and CB1 Receptor in GABA and Glutamate Release in the Basal Ganglia Background The basal ganglia are key structures in the brain responsible for motor control and reward-based behaviors. They receive excitatory inputs from the cortex and thalamus, with 80% of the synapses being glutamatergic, while the second mo...

Clinical Analysis of MOG Antibody-Associated Disease Overlapping with Anti-NMDAR Encephalitis Background In recent years, with the in-depth study of autoimmune encephalitis (AE) and demyelinating diseases of the central nervous system (CNS), scientists have identified some rare cases of overlapping syndromes. Among them, the overlap between MOG Ant...

Periodic and Aperiodic Components of Subthalamic Nucleus Activity Reflect Different Aspects of Motor Impairment in Parkinson’s Disease Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by core symptoms such as bradykinesia, rigidity, and tremor. Although the neurophysiology of PD has been extensively studied, ...

Oscillatory Transcranial Electrical Stimulation and the Quantitative Features of Phosphene Perception Background Introduction Phosphenes refer to the phenomenon of perceiving light points without any external visual stimuli. This phenomenon holds significant importance in visual neuroscience and consciousness studies, as it helps us understand how ...

Functional Connectivity of the Default Mode Network During Opioid Use and Cessation Background Opioid abuse has become a global public health issue, particularly in the United States, where opioid overdose deaths have tripled since 1999. Opioids not only lead to addiction but are also associated with chronic pain, immune system suppression, and neu...

The Role of Oxyglutamate Carrier in Cerebral Ischemia-Reperfusion Injury Academic Background Cerebral ischemia-reperfusion injury (I/R) is a significant issue in the treatment of ischemic stroke. Although rapid blood flow restoration through thrombectomy and intravenous rt-PA (recombinant tissue plasminogen activator) administration can effectively...

Metabolic Characteristics of Pancreatic Ductal Adenocarcinoma (PDAC) Subtypes Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of only 13%, making it the third leading cause of cancer-related deaths. The aggressiveness and chemoresistance of PDAC are closely linked to its complex metabo...

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

PAF1/HIF1α Axis Promotes Pancreatic Cancer Aggressiveness by Regulating Glycolytic Metabolism Background Pancreatic cancer (PC) is a highly aggressive malignant tumor, with pancreatic ductal adenocarcinoma (PDAC) being the most common type. Despite significant advancements in cancer treatment in recent years, the 5-year survival rate for pancreatic...