Report on the Paper “PICK: Predict and Mask for Semi-Supervised Medical Image Segmentation” Academic Background Accurate segmentation of medical images is crucial in clinical practice, as it provides vital insights into organ/tumor characteristics such as volume, location, and shape. Recent studies have highlighted the significant potential of data...

Report on the Paper “RepsNet: A Nucleus Instance Segmentation Model Based on Boundary Regression and Structural Re-parameterization” Academic Background Pathological diagnosis is the gold standard for tumor diagnosis, and nucleus instance segmentation is a key step in digital pathology analysis and pathological diagnosis. However, the computational...

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences Academic Background Lung cancer is one of the most frequently diagnosed cancers in the United States, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Among NSCLC, lung adenocarcinoma (LUAD) and l...

Mevalonate Kinase Impairs Anti-Tumor Immunity by Inhibiting the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer Academic Background Immune checkpoint blockade (ICB) therapy, particularly anti-PD-1 monoclonal antibodies, has been approved for the treatment of microsatellite instability colorectal cancer (MSI ...

Academic Background and Problem Statement Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer, accounting for 15-20% of all breast cancer cases. Due to the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), TNBC is insensitive to hormone the...

Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...

PRMT5-Regulated Splicing of DNA Repair Genes Drives Chemoresistance in Breast Cancer Stem Cells Academic Background Breast Cancer Stem Cells (BCSCs) are a rare subpopulation of cells within breast cancer that possess the ability to self-renew, initiate tumors, and metastasize. Despite their critical role in tumor initiation and progression, the mec...

Novel Germline Mutations in FUT7 and EXT1 Linked to Hereditary Multiple Exostoses Background Hereditary Multiple Exostoses (HME), also known as Hereditary Multiple Osteochondromas (HMO), is an autosomal dominant skeletal disorder characterized by the development of multiple cartilage-capped bone projections (osteochondromas). These osteochondromas ...

Mitochondrial Unfolded Protein Response-Dependent β-Catenin Signaling Promotes Neuroendocrine Prostate Cancer Academic Background Prostate cancer is the second most commonly diagnosed cancer in American men, second only to skin cancer. Although current treatments, such as androgen deprivation therapy (ADT), can induce remission in prostate cancer, ...

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...