SMARCA4 is a Haploinsufficient B Cell Lymphoma Tumor Suppressor that Fine-Tunes Centrocyte Cell Fate Decisions

Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...

Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...

Comprehensive Peripheral Blood Immunoprofiling Reveals Five Immunotypes with Immunotherapy Response Characteristics in Patients with Cancer

Research Report on the Analysis of Immunological Characteristics of Peripheral Blood in Cancer Patients Cancer is a major and pervasive health problem globally. Despite significant advances in cancer treatment in recent years, many challenges remain, including how to accurately predict patients’ responses to various treatments. Immunotherapy, parti...

Pharmacogenomic Profiling of Intra-Tumor Heterogeneity Using a Large Organoid Biobank of Liver Cancer

Pharmacogenomic Profiling of Intra-Tumor Heterogeneity Using a Large Organoid Biobank of Liver Cancer

Analysis of Intratumor Heterogeneity in Liver Cancer Using Pharmacogenomics: A Study Based on a Large-Scale Organoid Biobank Academic Background Primary liver cancer (PLC) is the third leading cause of cancer-related deaths worldwide, mainly comprising hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and a mixed form called co...

Leptomeningeal Collaterals Regulate Reperfusion in Ischemic Stroke and Rescue the Brain from Futile Recanalization

Leptomeningeal Collaterals Regulate Reperfusion in Ischemic Stroke and Rescue the Brain from Futile Recanalization

Leptomeningeal Glial Modulation of Ischemic Stroke Reperfusion to Avoid Futile Recanalization Background Ischemic Stroke is caused by the sudden blockage of cerebral arteries, leading to millions of disabilities and deaths globally each year. The current treatment for ischemic stroke primarily involves intravenous thrombolysis or mechanical thrombe...

Multi-Template Meta-Information Regularized Network for Alzheimer’s Disease Diagnosis Using Structural MRI

Multi-Template Meta-Information Regularized Network for Alzheimer’s Disease Diagnosis Using Structural MRI

Multi-template Meta-information Regularized Network for Alzheimer’s Disease Diagnosis: A Study Based on Structural MRI Research Background Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, and its diagnosis and early detection is a significant challenge in the medical field. Structural MRI (sMRI) is widely used in computer-aided...

Noise-Generating and Imaging Mechanism Inspired Implicit Regularization Learning Network for Low Dose CT Reconstruction

Noise-Generating and Imaging Mechanism Inspired Implicit Regularization Learning Network for Low Dose CT Reconstruction

Application of Implicit Regularization Learning Network Based on Noise Generation and Imaging Mechanisms in Low-Dose CT Reconstruction Low-Dose Computed Tomography (LDCT) has become an important tool in modern medical imaging, aiming to reduce radiation risks while maintaining image quality. However, reducing the X-ray dose often leads to data corr...

Time Efficient Ultrasound Localization Microscopy Based on a Novel Radial Basis Function 2D Interpolation

Time Efficient Ultrasound Localization Microscopy Based on a Novel Radial Basis Function 2D Interpolation

Time-Efficient Ultrasound Localization Microscopy Based on Novel Radial Basis Function Two-Dimensional Interpolation Introduction Ultrasound technology is a major medical imaging technique widely used for visualizing subcutaneous structures such as organs, muscles, and arteries due to its safety, cost-effectiveness, and non-invasiveness. However, t...

A Magnetic Particle Imaging Approach for Minimally Invasive Imaging and Sensing with Implantable Bioelectronic Circuits

Minimally Invasive Imaging and Sensing Methods Based on Magnetic Particle Imaging and the Application of Implanted Electronic Circuits Academic Background In modern medicine, minimally invasive and biocompatible implantable bioelectronics are widely used for long-term monitoring of physiological processes inside the body. However, methods for imagi...

Unsupervised Fusion of Misaligned PAT and MRI Images via Mutually Reinforcing Cross-Modality Image Generation and Registration

Unsupervised Fusion of Unaligned PAT and MRI Images Using Mutually Enhancing Cross-Modality Image Generation and Registration Methods Background and Research Objectives In recent years, photoacoustic tomography (PAT) and magnetic resonance imaging (MRI) have been widely used in preclinical research as cutting-edge biomedical imaging techniques. PAT...