Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...
Systematic Analysis of NDUFAF6 in Complex I Assembly and Mitochondrial Disease Background Mitochondrial complex I (CI) is a crucial component of the respiratory chain, playing an essential role in oxidative phosphorylation (OXPHOS) by introducing electrons into the mitochondrial respiratory chain and, together with complexes II-IV, generating and m...
Background In recent years, researchers have shown significant interest in electron-hole crystals within Mott insulators. These types of crystals can achieve quantum excited states, have the potential to support counterflow superfluidity and topological order, and possess long-range quantum entanglement characteristics. However, experimental eviden...
Unsaturation of Fatty Acids Promotes Pore-Forming Activity of Bax and Bak in Apoptosis Background Apoptosis is the major form of programmed cell death, involved in fundamental biological processes such as embryonic development, tissue homeostasis, and immune system functions. Dysregulation of apoptosis can lead to neurodegenerative diseases and tum...
Supramolecular Assembly-Activated Single-Molecule Phosphorescence Resonance Energy Transfer for Near-Infrared Targeted Cell Imaging In recent years, pure organic phosphorescence resonance energy transfer (PRET) research has become a hot topic. In this paper, the authors constructed a single-molecule PRET system with a large Stokes shift (367 nm) an...
Orthogonal Proteogenomic Analysis Identifies Druggable PA2G4-MYC Axis in 3q26 AML Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive malignancy. In particular, the 3q26 chromosomal abnormality subtype of AML has a complex pathogenic mechanism and lacks effective targeted therapies. To address this challenge, Matteo Marchesini and...
Interaction Between Gut Microbiota and Colonic Enteroendocrine Cells Regulates Host Metabolism Research Background Obesity is a major health issue in the 21st century and a significant factor contributing to various adverse health consequences such as diabetes, fatty liver disease, and cardiovascular diseases. Therefore, exploring the biological me...
Enhancing Super-Resolution Imaging and Volume Electron Microscopy with Deep Learning Algorithms Based on Diffusion Models Background Introduction Electron Microscopy (EM) as a high-resolution imaging tool has made significant breakthroughs in cell biology. Traditional EM techniques are primarily used for two-dimensional imaging, and although they h...
Preventing Diabetic Cardiomyopathy through Suppressing TGR5-Mediated Fatty Acid Uptake Background and Problem Statement Diabetic Cardiomyopathy (DBCM) is a severe complication frequently faced by diabetic patients, characterized by lipid accumulation in the myocardium and cardiac dysfunction. Bile acid metabolism plays a crucial role in cardiovascu...
Microbial Metabolite Ethylamine as FXR Agonist Promotes Polycystic Ovary Syndrome in Female Mice I. Research Background and Objectives Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting 6%-20% of women of reproductive age worldwide. Symptoms of PCOS include hyperandrogenemia, ovarian dysfunction, and polycystic ...