Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...
Connectomics Reconstruction Associated with Temporal Lobe Lesions and Their Surgical Resection Academic Background The human brain’s structural organization is increasingly conceptualized and analyzed from a network perspective, greatly enhancing understanding of health and disease. In recent years, thanks to advances in neuroimaging technology and...
KATP Channel Mutation Disrupts Hippocampal Network Activity and Nocturnal Gamma Wave Changes Research Background ATP-sensitive potassium (KATP) channels are crucial ion channels that link cellular metabolism with electrical activity. Studies have shown that high activity of KATP channels is closely related to a rare disease—Developmental delay, Epi...
Report on the Association Between Single Value Brain Activity Scores and the Progression of Alzheimer’s Disease Introduction Among the elderly population, cognitive decline and brain structural changes are widespread, even among healthy individuals1-3. Episodic memory, crucial for storing, maintaining, and retrieving single-event memories4, is espe...
Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...
Using Intracranial EEG-fMRI Mapping of Intermittent Discharges to Predict Epilepsy Surgery Outcomes Background and Objective Epilepsy is a common neurological disorder, and many patients are unresponsive to pharmacological treatments, making surgery one of the primary therapeutic options. However, accurately localizing the seizure onset zone (SOZ) ...
Research Background The core focus of this study is the manifestation of gray matter atrophy in neuroinflammatory diseases. Gray matter atrophy typically appears in four types of neuroinflammatory demyelinating diseases: Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) positive (AQP4+) and negative (AQP4-) for aquaporin-4 an...
Impact of Midbrain-Cortical Pathway Damage on Cognition, Apathy, and Gait in Small Vessel Disease Background and Research Motivation Small Vessel Disease (SVD) is a complex brain disorder mainly involving various pathological changes in small brain vessels, such as White Matter Hyperintensities (WMH), lacunar infarctions, and cerebral microbleeds. ...
The Impact of High Phenylalanine Exposure on Brain Structure in Adult Phenylketonuria Patients Background Phenylketonuria (PKU) is a rare hereditary metabolic disorder characterized by a deficiency of phenylalanine hydroxylase, leading to elevated levels of phenylalanine (Phe) in the blood and brain. If Phe levels are not strictly controlled during...
In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...